Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13273052 | 0.85 | CNR2 (0.47) | CNR2TAAR1ALOX5EGLN1MAOB | |
| SCHEMBL2554715 | 0.80 | RAB9A (0.45) | MAP4K4RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL30103039 | 0.80 | RAB9A (0.45) | MAP4K4RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL4592575 | 0.80 | GFER (0.46) | EGLN1MAP4K4RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL16675074 | 0.79 | CYP2A6 (0.51) | — | |
| SCHEMBL11172794 | 0.78 | CYP2A6 (0.58) | CNR2TAAR1ALOX5EGLN1MAP4K4 | |
| SCHEMBL2319381 | 0.75 | MAP4K4 (0.68) | CNR2TAAR1ALOX5MAP4K4BACE1 | |
| SCHEMBL422044 | 0.75 | SMN1; SMN2 (0.55) | CNR2TAAR1ALOX5EGLN1MAP4K4 | |
| SCHEMBL10898685 | 0.74 | MAP4K4 (0.50) | CNR2TAAR1ALOX5MAP4K4RAB9A | |
| SCHEMBL3721445 | 0.73 | MAPT (0.45) | CNR2TAAR1EGLN1MAP4K4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912969-A1 | PHENYLPYRIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017169-A1 | PHENYLPYRIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | disclosed |