Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772527 | 0.77 | LSS (0.44) | CES2 | |
| SCHEMBL5771539 | 0.75 | CES2 (0.50) | CES2ALDH1A1 | |
| SCHEMBL5772127 | 0.72 | LMNA (0.42) | GAASMN1; SMN2L3MBTL1POLQALDH1A1 | |
| SCHEMBL29499840 | 0.70 | GAA (0.58) | GAASMN1; SMN2L3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL1350804 | 0.70 | GAA (0.58) | GAASMN1; SMN2L3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL694388 | 0.69 | CFTR (0.69) | GAASMN1; SMN2L3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL2075208 | 0.69 | GAA (0.54) | GAASMN1; SMN2L3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL28188798 | 0.69 | GAA (0.57) | GAASMN1; SMN2L3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL16647662 | 0.69 | MRGPRX4 (0.51) | GAASMN1; SMN2L3MBTL1PDE2AKDM4E | |
| SCHEMBL26057003 | 0.68 | GAA (0.56) | GAASMN1; SMN2L3MBTL1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912969-A1 | PHENYLPYRIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017169-A1 | PHENYLPYRIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | disclosed |