Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.40 |
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2988212 | 0.75 | KIT (0.47) | L3MBTL1MMP2MMP9MMP8MMP13 | |
| SCHEMBL13608162 | 0.74 | AXL (0.51) | SMN1; SMN2KDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL9717891 | 0.73 | MMP2 (0.53) | L3MBTL1MMP2MMP9MMP8MMP13 | |
| SCHEMBL5306883 | 0.73 | MMP2 (0.56) | L3MBTL1MMP2MMP9MMP8MMP13 | |
| SCHEMBL13608566 | 0.73 | NPC1 (0.51) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL10206785 | 0.73 | MMP2 (0.34) | BRD4HTR7MMP2MMP9MMP8 | |
| SCHEMBL986878 | 0.72 | ALDH1A1 (0.54) | SMN1; SMN2KDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL13607760 | 0.72 | PTGES (0.51) | MMP2MMP9MMP8MAPK13MAPK12 | |
| SCHEMBL3320495 | 0.72 | EGFR (0.43) | HTR7SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL4487422 | 0.72 | MMP2 (0.58) | MMP2MMP9MMP8MMP13SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912987-A1 | HETEROCYCLIC BENZYLAMINO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-Roche AG (CH) | 2008-04-23 | — | — | EP | claimed |
| WO-2007014707-A1 | HETEROCYCLIC BENZYLAMINO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | claimed |
| EP-1912987-A1 | HETEROCYCLIC BENZYLAMINO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-Roche AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007014707-A1 | HETEROCYCLIC BENZYLAMINO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |