SCHEMBL4592641

SCHEMBL4592641

N#Cc1c(CBr)ccnc1Cl

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL6 P41182 10/20 0.35
HPGD P15428 3/20 0.33
ALDH1A1 P00352 3/20 0.33
LMNA P02545 2/20 0.33
KDM4E B2RXH2 2/20 0.33
MAPK1 P28482 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
MAPT P10636 2/20 0.33
POLB P06746 1/20 0.33
TSHR P16473 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
KMO O15229 1/20 0.32
KMT2A Q03164 3/20 0.31
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22904480 0.81 KMT2A (0.35) BCL6HPGDALDH1A1LMNAKDM4E
SCHEMBL29986005 0.81 AR (0.37) BCL6HPGDALDH1A1LMNAKDM4E
SCHEMBL27754223 0.76 ALDH1A1 (0.41) BCL6HPGDALDH1A1LMNAKDM4E
SCHEMBL4954240 0.75 BCL6 (0.40) BCL6HPGDALDH1A1LMNAKDM4E
SCHEMBL27810450 0.75 BCL6 (0.37) BCL6HPGDALDH1A1LMNAKDM4E
SCHEMBL1702773 0.74 LRRK2 (0.42) BCL6HPGDALDH1A1LMNAKDM4E
SCHEMBL844396 0.74 LMNA (0.31) LMNAMAPK1MAPTCYP3A4
SCHEMBL30072681 0.74 LRRK2 (0.42) BCL6HPGDALDH1A1LMNAKDM4E
SCHEMBL30319942 0.74 BCL6 (0.39) BCL6HPGDALDH1A1LMNAKDM4E
SCHEMBL26907733 0.72 BCL6 (0.32) BCL6ALDH1A1LMNAMAPK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931337-A2 PHENYL- AND PYRIDINYL- 1, 2 , 4 - OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS Sanofi-Aventis (FR) 2008-06-18 EP disclosed
EP-1931660-A2 PHENYL-[1,2,4]-OXADIAZOL-5-ONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS Sanofi-Aventis (FR) 2008-06-18 EP disclosed
WO-2007039177-A2 PHENYL- AND PYRIDINYL- 1, 2 , 4 - OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (DE) 2007-04-12 WO disclosed
WO-2007039178-A2 PHENYL-[1,2,4]-OXADIAZOL-5-ONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (DE) 2007-04-12 WO disclosed