Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.63 |
| ▸ | AKT2 | P31751 | 2/20 | 0.51 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | NEK4 | P51957 | 2/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.38 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240638 | 0.82 | AKT1 (0.51) | AKT1AKT2AKT3MMP12 | |
| SCHEMBL8243234 | 0.80 | AKT1 (0.57) | AKT1AKT2AKT3 | |
| SCHEMBL4584230 | 0.79 | AKT1 (0.48) | AKT1AKT2AKT3 | |
| SCHEMBL4585423 | 0.78 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL4583127 | 0.73 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL4592678 | 0.73 | AKT1 (0.46) | AKT1AKT2AKT3 | |
| SCHEMBL8243099 | 0.72 | AKT1 (0.47) | AKT1TACR3ROCK1ROCK2MAPK1 | |
| SCHEMBL8233993 | 0.72 | AKT1 (0.45) | AKT1AKT2AKT3DYRK1ADYRK1B | |
| SCHEMBL4592495 | 0.70 | AKT1 (0.46) | AKT1 | |
| SCHEMBL4581928 | 0.69 | CYP2C19 (0.38) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |