Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779425 | 0.88 | MAPK1 (0.46) | KDM4ETSHRHSD17B10RECQLGAA | |
| SCHEMBL4592913 | 0.88 | ITGA4 (0.34) | KDM4ETSHRHSD17B10GAAALDH1A1 | |
| SCHEMBL1780033 | 0.85 | KDM4E (0.44) | KDM4ETSHRHSD17B10GAAALDH1A1 | |
| SCHEMBL1778509 | 0.82 | RXFP1 (0.41) | KDM4ETSHRHSD17B10RECQLGAA | |
| SCHEMBL739402 | 0.80 | KDM4E (0.46) | KDM4ETSHRHSD17B10GAAALDH1A1 | |
| SCHEMBL1778410 | 0.79 | ALDH1A1 (0.40) | KDM4ETSHRHSD17B10RECQLGAA | |
| SCHEMBL742604 | 0.77 | KDM4E (0.46) | KDM4ETSHRHSD17B10GAAALDH1A1 | |
| SCHEMBL1778750 | 0.76 | BTK (0.45) | KDM4EHSD17B10ALDH1A1HPGDATM | |
| SCHEMBL740838 | 0.75 | KDM4E (0.42) | KDM4ETSHRHSD17B10ALDH1A1HPGD | |
| SCHEMBL1781437 | 0.74 | BTK (0.45) | KDM4ETSHRHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904503-A1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007009898-A1 | 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-01-25 | — | — | WO | disclosed |