Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779174 | 0.88 | RAB9A (0.39) | RAB9ANPC1TSHRKDM4EMEN1 | |
| SCHEMBL4592688 | 0.88 | KDM4E (0.44) | RAB9ANPC1TSHRKDM4EMEN1 | |
| SCHEMBL1780244 | 0.85 | HSD17B10 (0.38) | RAB9ANPC1TSHRKDM4EMEN1 | |
| SCHEMBL1779652 | 0.82 | RXFP1 (0.36) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL1777881 | 0.79 | HSD17B10 (0.35) | RAB9ANPC1TSHRKDM4EMEN1 | |
| SCHEMBL4592874 | 0.79 | RAB9A (0.41) | RAB9ANPC1KDM4ECSF1RALDH1A1 | |
| SCHEMBL1780614 | 0.76 | RAF1 (0.42) | CSF1R | |
| SCHEMBL1779425 | 0.74 | MAPK1 (0.46) | RAB9ANPC1TSHRKDM4EMEN1 | |
| SCHEMBL1778607 | 0.74 | ALDH1A1 (0.38) | RAB9ANPC1TSHRKDM4EMEN1 | |
| SCHEMBL1778870 | 0.73 | CSF1R (0.40) | MEN1KMT2ACSF1RGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904503-A1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007009898-A1 | 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-01-25 | — | — | WO | disclosed |