Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721248 | 0.83 | POLB (0.60) | POLBNPC1RAB9ASMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL3713052 | 0.82 | POLB (0.58) | POLBNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL5190567 | 0.80 | POLB (0.50) | POLBKDM4EMEN1KMT2A | |
| SCHEMBL14698727 | 0.80 | POLB (0.52) | POLBNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL27428109 | 0.78 | SIGMAR1 (0.54) | SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL17372632 | 0.77 | POLB (0.49) | POLBNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL8760671 | 0.77 | POLB (0.49) | POLBNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL3433977 | 0.77 | SMN1; SMN2 (0.65) | POLBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3431817 | 0.74 | CYP2C19 (0.57) | POLBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4725610 | 0.74 | P2RX7 (0.55) | POLBNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |