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SCHEMBL4592921

SCHEMBL4592921

COCCCN1CCOc2ccc(CO[C@H]3CN(C(=O)OCc4ccccc4)C[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]3c3ccc(COCCOC)cc3)cc21

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ REN P00797 5/20 0.34
▸ TMEM97 Q5BJF2 1/20 0.31
▸ SIGMAR1 Q99720 1/20 0.31
▸ LIPE Q05469 1/20 0.31
▸ PDE4B Q07343 1/20 0.31
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ NPSR1 Q6W5P4 1/20 0.30
▸ RORC P51449 1/20 0.30
▸ MKNK2 Q9HBH9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4582802 0.95 REN (0.35) RENTMEM97SIGMAR1PDE4BMEN1
SCHEMBL3272138 0.95 REN (0.35) RENTMEM97SIGMAR1PDE4BMEN1
SCHEMBL4599822 0.95 REN (0.36) RENRORC
SCHEMBL2340320 0.94 REN (0.35) RENTMEM97SIGMAR1PDE4BMEN1
SCHEMBL4592680 0.94 REN (0.35) RENTMEM97SIGMAR1PDE4BMEN1
SCHEMBL4592794 0.94 REN (0.34) RENTMEM97SIGMAR1PDE4BMEN1
SCHEMBL2338242 0.94 BMP1 (0.35) RENPDE4B
SCHEMBL2334830 0.94 REN (0.34) RENTMEM97SIGMAR1PDE4BMEN1
SCHEMBL1037839 0.93 REN (0.36) RENRORCMKNK2
SCHEMBL3268517 0.93 REN (0.34) RENTMEM97SIGMAR1PDE4BRORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1908762-A2 Organic compounds Speedel Experimenta AG (CH) 2008-04-09 — — EP disclosed
EP-1908761-A1 Organic compounds Speedel Experimenta AG (CH) 2008-04-09 — — EP disclosed