Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 9/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 9/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 8/20 | 0.41 |
| ▸ | CPA1 | P15085 | 7/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593507 | 0.85 | ICMT (0.51) | FFAR1MMP12TRPV1MMEICMT | |
| SCHEMBL5505220 | 0.74 | MME (0.49) | FFAR1MMEACEACE2CPA1 | |
| SCHEMBL5808516 | 0.73 | FFAR1 (0.58) | FFAR1MMP12FFAR4HDAC2 | |
| SCHEMBL11856516 | 0.73 | FNTA (0.51) | — | |
| SCHEMBL3863272 | 0.73 | FNTA (0.51) | — | |
| SCHEMBL3860439 | 0.73 | FNTA (0.51) | — | |
| SCHEMBL3863270 | 0.73 | FNTA (0.51) | — | |
| SCHEMBL5439940 | 0.73 | ICMT (0.75) | ICMTACE | |
| SCHEMBL14596271 | 0.73 | ICMT (0.75) | ICMTACE | |
| SCHEMBL2813151 | 0.72 | FFAR1 (0.53) | FFAR1MMP12TRPV1FFAR4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613585-A4 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA AND CANCER BASED UPON INHIBITORS OF ISOPRENYLCYSTEINE METHYLTRANSFERASE | PURDUE RESEARCH FOUNDATION (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1613585-A2 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA AND CANCER BASED UPON INHIBITORS OF ISOPRENYLCYSTEINE METHYLTRANSFERASE | PURDUE RESEARCH FOUNDATION (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087064-A2 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA AND CANCER BASED UPON INHIBITORS OF ISOPRENYLCYSTEINE METHYLTRANSFERASE | PURDUE RESEARCH FOUNDATION (US) | 2004-10-14 | — | — | WO | disclosed |