Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 9/20 | 0.39 |
| ▸ | ACE | P12821 | 8/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 8/20 | 0.39 |
| ▸ | CPA1 | P15085 | 6/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592994 | 0.85 | FFAR1 (0.46) | ICMTFFAR1MMP12MMEACE | |
| SCHEMBL13129949 | 0.76 | FFAR1 (0.46) | ICMTFFAR1MMP12TRPV1FFAR4 | |
| SCHEMBL2815696 | 0.76 | FFAR1 (0.46) | ICMTFFAR1MMP12TRPV1FFAR4 | |
| SCHEMBL5445097 | 0.76 | ICMT (0.72) | ICMTACE | |
| SCHEMBL14596300 | 0.76 | ICMT (0.72) | ICMTACE | |
| SCHEMBL14596301 | 0.75 | ICMT (0.46) | ICMTFFAR1MMP12TRPV1FFAR4 | |
| SCHEMBL13883693 | 0.73 | ICMT (0.51) | ICMTFFAR1MMP12TRPV1FFAR4 | |
| SCHEMBL332020 | 0.72 | MAPT (0.52) | ACE | |
| SCHEMBL388271 | 0.72 | MAPT (0.52) | ACE | |
| SCHEMBL1762279 | 0.72 | MAPT (0.52) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613585-A4 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA AND CANCER BASED UPON INHIBITORS OF ISOPRENYLCYSTEINE METHYLTRANSFERASE | PURDUE RESEARCH FOUNDATION (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1613585-A2 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA AND CANCER BASED UPON INHIBITORS OF ISOPRENYLCYSTEINE METHYLTRANSFERASE | PURDUE RESEARCH FOUNDATION (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087064-A2 | COMPOUNDS AND METHODS FOR USE IN TREATING NEOPLASIA AND CANCER BASED UPON INHIBITORS OF ISOPRENYLCYSTEINE METHYLTRANSFERASE | PURDUE RESEARCH FOUNDATION (US) | 2004-10-14 | — | — | WO | disclosed |