Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12559796 | 0.89 | GAA (0.34) | LMNAHSD17B10GAATDP1 | |
| SCHEMBL8343989 | 0.86 | SMPD1 (0.44) | FDPSHTR2CSMPD1CES2 | |
| SCHEMBL8346418 | 0.86 | SMPD1 (0.44) | FDPSHTR2CSMPD1CES2 | |
| SCHEMBL8346454 | 0.86 | SMPD1 (0.44) | FDPSHTR2CSMPD1CES2 | |
| SCHEMBL12559721 | 0.85 | NAAA (0.32) | LMNAHSD17B10HTR2CALDH1A1GAA | |
| SCHEMBL30082476 | 0.84 | LMNA (0.35) | LMNAHSD17B10FDPSALDH1A1 | |
| SCHEMBL4198525 | 0.83 | GAA (0.31) | GAA | |
| SCHEMBL3075458 | 0.82 | ALDH1A1 (0.36) | LMNAHTR2CALDH1A1TLR8TLR7 | |
| SCHEMBL6784510 | 0.82 | ALDH1A1 (0.39) | LMNAHSD17B10FDPSALDH1A1GAA | |
| SCHEMBL452970 | 0.82 | GAA (0.39) | LMNAHSD17B10FDPSALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904461-A2 | CYCLIC ANILINOPYRIDINOTRIAZINES AS GSK-3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007003525-A2 | CYCLIC ANILINO-PYRIDINOTRIAZINES AS GSK-3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-11 | — | — | WO | disclosed |