Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 11/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457569 | 0.78 | CYP2C19 (0.58) | CYP2C19HTR6METDRD2HTR2A | |
| SCHEMBL29941031 | 0.78 | CYP2C19 (0.58) | CYP2C19HTR6METDRD2HTR2A | |
| SCHEMBL30135007 | 0.77 | CYP2C19 (0.50) | CYP2C19HTR6METPIK3C3DRD2 | |
| SCHEMBL25323786 | 0.76 | CYP2C19 (0.46) | CYP2C19HTR6METPIK3C3DRD2 | |
| SCHEMBL4633196 | 0.76 | CYP2C19 (0.46) | CYP2C19HTR6METPIK3C3PKM | |
| SCHEMBL30509465 | 0.76 | CYP2C19 (0.46) | CYP2C19HTR6METPIK3C3DRD2 | |
| SCHEMBL4583237 | 0.75 | PIK3C3 (0.45) | CYP2C19HTR6PIK3C3DRD2HTR2A | |
| SCHEMBL30135143 | 0.74 | CYP2C19 (0.51) | CYP2C19HTR6METPIK3C3DRD2 | |
| SCHEMBL31668630 | 0.74 | HTR6 (0.50) | CYP2C19HTR6METPIK3C3DRD2 | |
| SCHEMBL31668596 | 0.73 | CYP2C19 (0.45) | CYP2C19HTR6METPIK3C3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |