Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036939 | 0.91 | TSHR (0.63) | ALDH1A1TSHRACHEGAAMAPT | |
| SCHEMBL2026676 | 0.89 | ALDH1A1 (0.78) | ALDH1A1TSHRACHEGAAMAPT | |
| SCHEMBL30469275 | 0.89 | ALDH1A1 (0.78) | ALDH1A1TSHRACHEGAAMAPT | |
| Water SCHEMBL29134001 | 0.87 | ALDH1A1 (0.75) | ALDH1A1TSHRACHEGAAMAPT | |
| SCHEMBL30360587 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TSHRACHEGAAMAPT | |
| SCHEMBL7142305 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TSHRACHEGAAMAPT | |
| SCHEMBL26673982 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TSHRMAPTNPC1RAB9A | |
| SCHEMBL23542887 | 0.82 | MAOA (0.67) | ALDH1A1ACHEMAPTNPC1HPGD | |
| SCHEMBL1040119 | 0.82 | MAOA (0.67) | ALDH1A1ACHEMAPTNPC1HPGD | |
| Dinitrophenylene SCHEMBL27461706 | 0.80 | ALDH1A1 (0.63) | ALDH1A1TSHRACHEGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948616-A1 | 2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR | N.V. Organon (NL) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054480-A1 | 2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR | N.V. ORGANON (NL) | 2007-05-18 | — | — | WO | disclosed |