Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | IDH2 | P48735 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28781470 | 0.81 | NOTUM (0.54) | LMNAPOLBKIF11IDH2AURKA | |
| SCHEMBL27641960 | 0.75 | KIF11 (0.50) | LMNAPOLBKIF11IDH2AURKA | |
| SCHEMBL825684 | 0.73 | CYP1A2 (0.38) | LMNAALDH1A1GAATDP1L3MBTL1 | |
| SCHEMBL29748950 | 0.70 | MAPT (0.58) | KIF11IDH2MAPTALDH1A1GAA | |
| SCHEMBL2925587 | 0.70 | MAPT (0.58) | KIF11IDH2MAPTALDH1A1GAA | |
| SCHEMBL394991 | 0.70 | KIF11 (0.70) | LMNAKIF11IDH2AURKAMAPT | |
| SCHEMBL11286034 | 0.70 | NOTUM (0.64) | LMNAMAPTALDH1A1HTTRAB9A | |
| SCHEMBL1807928 | 0.70 | MEN1 (0.56) | LMNAPOLBIDH2MAPTALDH1A1 | |
| SCHEMBL30402678 | 0.70 | NOTUM (0.64) | LMNAMAPTALDH1A1HTTRAB9A | |
| SCHEMBL30047371 | 0.70 | HTT (0.55) | LMNAPOLBMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910347-A2 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS | MEDIVIR AB (SE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007017144-A2 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS | MEDIVIR AB (SE) | 2007-02-15 | — | — | WO | disclosed |