Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 9/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 5/20 | 0.37 |
| ▸ | PPARA | Q07869 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593246 | 0.94 | SSTR5 (0.41) | RENSSTR5HDAC6HRH1SSTR1 | |
| SCHEMBL4594763 | 0.92 | SSTR5 (0.41) | RENSSTR5HDAC6HRH1SSTR1 | |
| SCHEMBL4594609 | 0.90 | SSTR5 (0.38) | SSTR5NPC1L1PPARDPPARAPPARG | |
| SCHEMBL4594185 | 0.88 | SSTR5 (0.42) | RENSSTR5HDAC6HRH1SSTR1 | |
| SCHEMBL4593591 | 0.86 | REN (0.43) | RENSSTR5HDAC6HRH1PPARA | |
| SCHEMBL4593573 | 0.85 | SSTR5 (0.39) | SSTR5PPARDPPARAPPARGKCNH2 | |
| SCHEMBL5485903 | 0.85 | HDAC6 (0.46) | RENSSTR5HDAC6HRH1SSTR1 | |
| SCHEMBL5484863 | 0.83 | SSTR5 (0.57) | RENSSTR5HDAC6HRH1SSTR1 | |
| SCHEMBL4594636 | 0.82 | MAPT (0.46) | RENSSTR5HDAC6SSTR1KCNH2 | |
| SCHEMBL4594820 | 0.81 | SSTR5 (0.39) | SSTR5PPARDPPARAPPARGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | claimed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | claimed |
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |