Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 12/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | REN | P00797 | 3/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380236 | 0.89 | SSTR5 (0.54) | HDAC6SSTR5KCNH2MAPK1SSTR1 | |
| SCHEMBL5484220 | 0.88 | SSTR5 (0.44) | HDAC6SSTR5KCNH2HRH1SSTR1 | |
| SCHEMBL4594636 | 0.87 | MAPT (0.46) | HDAC6SSTR5KCNH2RENSSTR1 | |
| SCHEMBL4594763 | 0.87 | SSTR5 (0.41) | HDAC6SSTR5KCNH2HRH1REN | |
| SCHEMBL5484863 | 0.87 | SSTR5 (0.57) | HDAC6SSTR5KCNH2HRH1REN | |
| SCHEMBL4594278 | 0.86 | MAPT (0.46) | HDAC6SSTR5HRH1RENMAPT | |
| SCHEMBL1379151 | 0.86 | SSTR5 (0.56) | HDAC6SSTR5KCNH2HRH1SSTR1 | |
| SCHEMBL4594185 | 0.86 | SSTR5 (0.42) | HDAC6SSTR5KCNH2HRH1REN | |
| SCHEMBL4593246 | 0.85 | SSTR5 (0.41) | HDAC6SSTR5KCNH2HRH1REN | |
| SCHEMBL4593310 | 0.85 | REN (0.41) | HDAC6SSTR5KCNH2HRH1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |