Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307946 | 0.84 | HSPB1 (0.40) | HSPB1ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL307788 | 0.79 | MET (0.44) | HSPB1ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL307501 | 0.77 | MET (0.43) | HSPB1ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL10254970 | 0.73 | HSPB1 (0.50) | HSPB1ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL306564 | 0.68 | MET (0.41) | HSPB1MET | |
| SCHEMBL7412479 | 0.68 | PNMT (0.47) | ALDH1A1MAPTMAPK1L3MBTL1PNMT | |
| SCHEMBL4790042 | 0.67 | PNMT (0.48) | MAPTPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL15820188 | 0.66 | HSPB1 (0.80) | HSPB1ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL105274 | 0.65 | MET (0.39) | HSPB1ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL22114132 | 0.64 | HSPB1 (0.63) | HSPB1ALDH1A1MAPTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957498-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | MethylGene Inc. (CA) | 2008-08-20 | — | — | EP | disclosed |
| WO-2008041053-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2008-04-10 | — | — | WO | disclosed |