Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 13/20 | 0.42 |
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594363 | 0.93 | SSTR5 (0.41) | SSTR5HRH1KDM4EALDH1A1SSTR1 | |
| SCHEMBL4594029 | 0.90 | SSTR5 (0.41) | SSTR5HRH1KDM4EALDH1A1SSTR1 | |
| SCHEMBL4593843 | 0.89 | SSTR5 (0.43) | SSTR5HRH1CMKLR1NPC1SSTR1 | |
| SCHEMBL4594452 | 0.89 | SSTR5 (0.41) | SSTR5HRH1CMKLR1MAPK1KDM4E | |
| SCHEMBL4594138 | 0.87 | SSTR5 (0.44) | SSTR5HRH1NPC1SSTR1KCNH2 | |
| SCHEMBL5484220 | 0.87 | SSTR5 (0.44) | SSTR5HRH1NPC1SSTR1KCNH2 | |
| SCHEMBL4593945 | 0.85 | SSTR5 (0.41) | SSTR5HRH1SSTR1KCNH2SLC6A2 | |
| SCHEMBL5488609 | 0.84 | SSTR5 (0.41) | SSTR5HRH1HTR2BSLC6A2SLC6A4 | |
| SCHEMBL4594237 | 0.84 | SSTR5 (0.36) | SSTR5HRH1MAPK1KCNH2HTR2B | |
| SCHEMBL1378217 | 0.84 | SSTR5 (0.49) | SSTR5HRH1SSTR1KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | claimed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | claimed |
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |