SCHEMBL459354

SCHEMBL459354

Cc1onc(-c2ccccc2Cl)c1C(=O)O

nearest known ligand 0.76

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.76
LMNA P02545 2/20 0.71
GPBAR1 Q8TDU6 7/20 0.70
CYP2C19 P33261 2/20 0.68
MAPT P10636 2/20 0.67
L3MBTL1 Q9Y468 1/20 0.65
NPC1 O15118 1/20 0.64
ALDH1A1 P00352 1/20 0.64
POLB P06746 1/20 0.64
HPGD P15428 1/20 0.64
PLAU P00749 1/20 0.63
ELANE P08246 1/20 0.63
EPAS1 Q99814 1/20 0.63
CYP3A4 P08684 1/20 0.63
HTT P42858 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30395456 1.00 HSD17B10 (0.76) HSD17B10LMNAGPBAR1CYP2C19MAPT
Hydrochloric Acid SCHEMBL11554371 0.98 HSD17B10 (0.74) HSD17B10LMNAGPBAR1CYP2C19MAPT
SCHEMBL27910275 0.89 HSD17B10 (0.78) HSD17B10LMNAGPBAR1CYP2C19MAPT
SCHEMBL14765558 0.88 MAPT (0.77) HSD17B10LMNAGPBAR1CYP2C19MAPT
SCHEMBL32679558 0.88 HSD17B10 (0.76) HSD17B10LMNAGPBAR1CYP2C19MAPT
SCHEMBL315858 0.88 HSD17B10 (0.76) HSD17B10LMNAGPBAR1CYP2C19MAPT
SCHEMBL10520547 0.88 HSD17B10 (0.76) HSD17B10LMNAGPBAR1CYP2C19MAPT
SCHEMBL903109 0.87 HSD17B10 (1.00) HSD17B10LMNAGPBAR1CYP2C19MAPT
SCHEMBL8548060 0.87 HSD17B10 (0.74) HSD17B10LMNAGPBAR1CYP2C19MAPT
SCHEMBL12457425 0.84 GPBAR1 (0.59) HSD17B10LMNAGPBAR1CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180273906-A1 MICROVESICLE AND STEM CELL COMPOSITIONS FOR THERAPEUTIC APPLICATIONS IPS HEART 2018-09-27 US claimed
EP-1745009-B1 HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES GRUENENTHAL GMBH (DE) 2012-11-14 EP claimed
JP-2007536321-A 2007-12-13 JP claimed
US-20070129369-A1 Heteroaryl substituted cyclohexyl-1,4-diamine compounds GRUENENTHAL GMBH (DE) 2007-06-07 US claimed
EP-1745009-A1 HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES Grünenthal GmbH (DE) 2007-01-24 EP claimed
US-20060058351-A1 Novel ligands that modulate LXR-type receptors and cosmetic/pharmaceutical applications thereof GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2006-03-16 US claimed
EP-1599447-A1 LIGANDS THAT MODULATE LXR-TYPE RECEPTORS Galderma Research & Development, S.N.C. (FR) 2005-11-30 EP claimed
WO-2005110971-A1 HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES Grünenthal GmbH (DE) 2005-11-24 WO claimed
CN-1228332-C Chemical synthesis method of 3-(2-chlorophenyl)-5-methyl-4-isoxazole formyl chloride UNIV ZHEJIANG TECHNOLOGY (CN) 2005-11-23 CN claimed
CN-1535960-A Chemical synthesis method of 3-(2-chlorophenyl)-5-methyl-4-isoxazole formyl chloride 浙江工业大学 2004-10-13 CN claimed
WO-2004076418-A1 LIGANDS THAT MODULATE LXR-TYPE RECEPTORS GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2004-09-10 WO claimed
US-4007168-A Process for preparing penicillins derivatives PALOMO COLL A L 1977-02-08 US claimed
WO-2026085609-A1 METHODS FOR PRODUCING POLYUNSATURATED FATTY ACIDS FROM AQUACULTURE RESIDUES LES LABORATOIRES ISO-BIOKEM INC. (CA) 2026-04-30 WO disclosed
EP-4590301-A1 COMPOUNDS FOR TREATMENT OF INFLAMMATORY PROCESSES THORNE LIMITED (CA) 2025-07-30 EP disclosed
CN-114058321-B Encapsulant for display 日本化药株式会社 2025-05-23 CN disclosed
CN-119463228-A Glove manufacturing method 日本瑞翁株式会社 2025-02-18 CN disclosed
US-4230849-A Process for the activation of carboxylic acids ANTIBIOTICOS, S.A. (ES) 1980-10-28 US disclosed
US-4172198-A ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1979-10-23 US disclosed
US-4113940-A ANTIMICROBIAL FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1978-09-12 US disclosed
US-3984397-A CYCLIZATION FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1976-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180273906-A1 MICROVESICLE AND STEM CELL COMPOSITIONS FOR THERAPEUTIC APPLICATIONS EXOSC9, EXOSC5, EXOSC4 HSD17B10 3195/4885LMNA 245/4885GPBAR1 4716/4885
US-20070129369-A1 Heteroaryl substituted cyclohexyl-1,4-diamine compounds DDC, DPYD, PKD1 HSD17B10 394/4885LMNA 2080/4885GPBAR1 181/4885
US-20060058351-A1 Novel ligands that modulate LXR-type receptors and cosmetic/pharmaceutical applications thereof NR1H2, NR1H3, RXRG HSD17B10 235/4885LMNA 1835/4885GPBAR1 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.