Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593901 | 0.89 | KDR (0.44) | KDR | |
| SCHEMBL4593297 | 0.88 | GPR119 (0.52) | KDRGPR119 | |
| SCHEMBL4593903 | 0.82 | KDR (0.44) | KDR | |
| SCHEMBL4616997 | 0.82 | KDR (0.54) | KDR | |
| SCHEMBL4593293 | 0.79 | KDR (0.41) | KDR | |
| SCHEMBL4593593 | 0.78 | KDR (0.42) | KDR | |
| SCHEMBL4587497 | 0.77 | KDR (0.43) | KDR | |
| SCHEMBL4586348 | 0.77 | KDR (0.47) | KDR | |
| SCHEMBL4587631 | 0.76 | GPR119 (0.54) | KDRGPR119 | |
| SCHEMBL4594092 | 0.74 | NSD2 (0.49) | KDRGPR119DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |