Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.46 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.46 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 5/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653908 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL28904818 | 0.88 | TDP1 (0.50) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL31236206 | 0.85 | TSHR (0.45) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL8526617 | 0.85 | TSHR (0.45) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL9343855 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL8146477 | 0.83 | TDP1 (0.46) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL7734435 | 0.82 | TSHR (0.48) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL28904803 | 0.79 | GPR35 (0.52) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL9787411 | 0.78 | ALDH1A1 (0.47) | ALDH1A1TSHRTDP1CYP3A4HIF1A | |
| SCHEMBL7113012 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TSHRTDP1CYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294742-A | Process for preparing 3,5-difluoroaniline | HOECHST ATKIENGESELLSCHAFT (DE) | 1994-03-15 | — | — | US | claimed |
| EP-1594504-A4 | NOVEL IRREVERSIBLE INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE AND USES THEREOF FOR THERAPY AND DIAGNOSIS | T K SIGNAL LTD (IL) | 2008-12-17 | — | — | EP | disclosed |
| EP-1673110-A2 | RADIOLABELED ANILINOQUINAZOLINES AND THEIR USE IN RADIOIMAGING AND RADIOTHERAPY | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2006-06-28 | — | — | EP | disclosed |
| EP-1594504-A2 | NOVEL IRREVERSIBLE INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE AND USES THEREOF FOR THERAPY AND DIAGNOSIS | T.K. Signal Ltd. (IL) | 2005-11-16 | — | — | EP | disclosed |
| WO-2005023315-A2 | RADIOLABELED ANILINOQUINAZOLINES AND THEIR USE IN RADIOIMAGING AND RADIOTHERAPY | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2005-03-17 | — | — | WO | disclosed |
| WO-2004064718-A2 | IRREVERSIBLE INHIBITORS OF EGF RECEPTOR TYROSINE KINASES AND USES THEREOF | T.K. SIGNAL LTD. (IL) | 2004-08-05 | — | — | WO | disclosed |
| EP-0794936-B1 | METHOD FOR PREPARING FLUOROANILINES FROM NITROFLUOROBENZENE COMPOUNDS | RHODIA CHIMIE SA (FR) | 1999-03-17 | — | — | EP | disclosed |
| US-5856577-A | Process for the preparation of fluoroanilines from fluorinated nitrated benzene compounds | RHONE-POULENC CHIMIE (FR) | 1999-01-05 | — | — | US | disclosed |
| EP-0875497-A2 | Method for preparing fluoroanilines from nitrofluorobenzene compounds | RHODIA CHIMIE (FR) | 1998-11-04 | — | — | EP | disclosed |
| EP-0794936-A1 | METHOD FOR PREPARING FLUOROANILINES FROM NITROFLUOROBENZENE COMPOUNDS | RHONE-POULENC CHIMIE (FR) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016926-A1 | METHOD FOR PREPARING FLUOROANILINES FROM NITROFLUOROBENZENE COMPOUNDS | RHONE-POULENC CHIMIE (FR) | 1996-06-06 | — | — | WO | disclosed |
| EP-0562435-B1 | Process for the preparation of 3,5-difluoroaniline | HOECHST AG (DE) | 1995-06-07 | — | — | EP | disclosed |
| US-5294742-A | Process for preparing 3,5-difluoroaniline | HOECHST ATKIENGESELLSCHAFT (DE) | 1994-03-15 | — | — | US | disclosed |
| EP-0562435-A1 | Process for the preparation of 3,5-difluoroaniline | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |