Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | NQO1 | P15559 | 1/20 | 0.52 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75226 | 1.00 | GRM5 (0.53) | GRM5KCNH2NQO1SOS2NCF1 | |
| SCHEMBL27416745 | 1.00 | GRM5 (0.53) | GRM5KCNH2NQO1SOS2NCF1 | |
| Methane SCHEMBL27560165 | 0.98 | GRM5 (0.52) | GRM5KCNH2NQO1SOS2NCF1 | |
| Hydrochloric Acid SCHEMBL28328423 | 0.98 | GRM5 (0.52) | GRM5KCNH2NQO1SOS2NCF1 | |
| Hydrazine SCHEMBL28226443 | 0.96 | GRM5 (0.50) | GRM5KCNH2NQO1SOS2NCF1 | |
| Ethane SCHEMBL28069598 | 0.96 | NQO1 (0.53) | GRM5KCNH2NQO1SOS2NCF1 | |
| Ethylene SCHEMBL4594450 | 0.96 | GRM5 (0.50) | GRM5KCNH2NQO1SOS2NCF1 | |
| SCHEMBL15877631 | 0.89 | GRM5 (0.62) | GRM5KCNH2NQO1SOS2NCF1 | |
| Quinoline SCHEMBL28130812 | 0.89 | ALDH1A1 (0.61) | GRM5KCNH2NQO1SOS2NCF1 | |
| Pyrrole SCHEMBL28298992 | 0.89 | GRM5 (0.45) | GRM5KCNH2NQO1SOS2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386511-B2 | METHODS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2024-03-20 | — | — | EP | claimed |
| EP-4649139-A1 | METHODS FOR EXPANDING IMMUNE CELLS AND RELATED COMPOSITIONS AND USES THEREOF | Nkarta, Inc. (US) | 2025-11-19 | — | — | EP | disclosed |
| WO-2025011623-A1 | CYANOQUINOLINE-TARGETING PROTEIN DEGRADATION MOLECULE, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海壹迪生物技术有限公司 | 2025-01-16 | — | — | WO | disclosed |
| US-12172965-B2 | Drug conjugate comprising quinoline derivatives | Universite Paris-Saclay (FR) | 2024-12-24 | — | — | US | disclosed |
| CN-119019327-A | Acetylation method of quinoline or isoquinoline compounds | 常州工程职业技术学院 | 2024-11-26 | — | — | CN | disclosed |
| WO-2024163619-A1 | METHODS FOR EXPANDING IMMUNE CELLS AND RELATED COMPOSITIONS AND USES THEREOF | NKARTA, INC. (US) | 2024-08-08 | — | — | WO | disclosed |
| CN-112710838-B | Application of quinoline nitrile derivative in detection of protein by protein imprinting method and preparation method thereof | 华东理工大学 | 2024-08-06 | — | — | CN | disclosed |
| EP-3853208-B1 | DRUG CONJUGATE COMPRISING QUINOLINE DERIVATIVES | CENTRE NAT RECH SCIENT (FR) | 2023-06-07 | — | — | EP | disclosed |
| US-11638706-B2 | Methods for treating Huntington's disease | PTC THERAPEUTICS, INC. (US) | 2023-05-02 | — | — | US | disclosed |
| US-11608501-B2 | Methods for modifying RNA splicing | PTC THERAPEUTICS, INC. (US) | 2023-03-21 | — | — | US | disclosed |
| US-20220023435-A1 | DRUG CONJUGATE COMPRISING QUINOLINE DERIVATIVES | Universite Paris-Saclay (FR) | 2022-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220023435-A1 | DRUG CONJUGATE COMPRISING QUINOLINE DERIVATIVES | HRH3, ABCC3, ORC3 | GRM5 2140/4885KCNH2 1051/4885NQO1 98/4885 |
| US-11608501-B2 | Methods for modifying RNA splicing | RBM17, SNRPA1, SNRPE | GRM5 2805/4885KCNH2 4351/4885NQO1 2738/4885 |
| US-12172965-B2 | Drug conjugate comprising quinoline derivatives | HRH3, ABCC3, ORC3 | GRM5 2140/4885KCNH2 1051/4885NQO1 98/4885 |
| US-11638706-B2 | Methods for treating Huntington's disease | HTT, HYPK, FH | GRM5 256/4885KCNH2 2233/4885NQO1 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.