Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1692765 | 0.91 | RAB9A (0.46) | RAB9AHSD11B1JAK2JAK1AKR1C3 | |
| SCHEMBL27357653 | 0.88 | RAB9A (0.43) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL4687962 | 0.88 | RAB9A (0.46) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL30885565 | 0.84 | GAA (0.50) | AKR1C3GAAHTTNOS3NOS2 | |
| SCHEMBL2012460 | 0.84 | RAB9A (0.44) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL12760596 | 0.84 | RAB9A (0.44) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL4685564 | 0.84 | RAB9A (0.44) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL8550495 | 0.83 | RAB9A (0.46) | RAB9AHSD11B1JAK2JAK1AKR1C3 | |
| SCHEMBL14405029 | 0.82 | RAB9A (0.47) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL1693216 | 0.81 | RAB9A (0.48) | RAB9AHSD11B1JAK2JAK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |