Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012460 | 1.00 | RAB9A (0.44) | RAB9AJAK1JAK2HSD11B1TPSAB1 | |
| SCHEMBL5262093 | 0.91 | RAB9A (0.49) | RAB9AJAK1JAK2HSD11B1TPSAB1 | |
| SCHEMBL2894884 | 0.91 | TPSAB1 (0.47) | RAB9AJAK1JAK2HSD11B1TPSAB1 | |
| SCHEMBL5568829 | 0.89 | RAB9A (0.43) | RAB9AJAK1JAK2HSD11B1GAA | |
| SCHEMBL4687962 | 0.86 | RAB9A (0.46) | RAB9AJAK1JAK2HSD11B1GAA | |
| SCHEMBL4685564 | 0.85 | RAB9A (0.44) | RAB9AJAK1JAK2HSD11B1GAA | |
| SCHEMBL4594562 | 0.84 | RAB9A (0.43) | RAB9AJAK1JAK2HSD11B1GAA | |
| SCHEMBL27357653 | 0.84 | RAB9A (0.43) | RAB9AJAK1JAK2HSD11B1GAA | |
| SCHEMBL14405029 | 0.84 | RAB9A (0.47) | RAB9AJAK1JAK2HSD11B1GAA | |
| SCHEMBL3825100 | 0.82 | HSD11B1 (0.43) | RAB9AJAK1JAK2HSD11B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2503890-A1 | AZABENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-10-03 | — | — | EP | disclosed |