Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212743 | 0.79 | LMNA (0.33) | ALDH1A1MAPTLMNA | |
| SCHEMBL179565 | 0.79 | CYP1A2 (0.50) | ALDH1A1HSD17B10TSHRKDM4EHPGD | |
| SCHEMBL29158197 | 0.76 | CYP3A4 (0.47) | CYP3A4ALDH1A1HSD17B10TSHRSNCA | |
| SCHEMBL3015836 | 0.76 | ALDH1A1 (0.44) | CYP3A4ALDH1A1HSD17B10TSHRKDM4E | |
| SCHEMBL1437231 | 0.76 | KDM4E (0.39) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL25475161 | 0.76 | FNTA (0.33) | ALDH1A1MAPTLMNA | |
| SCHEMBL3555935 | 0.75 | — | — | |
| SCHEMBL1397897 | 0.75 | CYP3A4 (0.59) | CYP3A4ALDH1A1HSD17B10TSHRSNCA | |
| SCHEMBL27493011 | 0.75 | ALDH1A1 (0.35) | ALDH1A1KDM4E | |
| SCHEMBL8055864 | 0.73 | MEN1 (0.54) | CYP3A4ALDH1A1HSD17B10TSHRSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070036718-A1 | Radio-halogenated carboxylic ester derivatives of phenylethyl imidazole tomography/scintigraphy imaging for detection of adrenal cortical pathology, e.g. incidentaloma, adenoma, primary and metastatic cortical carcinoma; highly selective with a high rate of accumulation in adrenals; antitumor agents | ZOLLE, ILSE (AT) | 2007-02-15 | — | — | US | claimed |
| US-20050033060-A1 | Radiolabelled phenylethyl imidazole caboxylic acid ester derivatives | ZOLLE, ILSE (AT) | 2005-02-10 | — | — | US | claimed |
| US-4055573-A | TO 4-HYDROXYMETHYL OR ALKOXYMETHYL IMIDAZOLES | SMITHKLINE CORPORATION (US) | 1977-10-25 | — | — | US | claimed |
| US-20080009506-A1 | Imidazole Compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-01-10 | — | — | US | disclosed |
| EP-0338939-A1 | Histamine derivative, process for his preparation and his therapeutic application | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1989-10-25 | — | — | EP | disclosed |
| US-4322539-A | BY REACTION WITH AMINOALKYLENE THIOLS | ETHYL CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4055573-A | TO 4-HYDROXYMETHYL OR ALKOXYMETHYL IMIDAZOLES | SMITHKLINE CORPORATION (US) | 1977-10-25 | — | — | US | disclosed |
| US-4055573-A | TO 4-HYDROXYMETHYL OR ALKOXYMETHYL IMIDAZOLES | SMITHKLINE CORPORATION (US) | 1977-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070036718-A1 | Radio-halogenated carboxylic ester derivatives of phenylethyl imidazole tomography/scintigraphy imaging for detection of adrenal cortical pathology, e.g. incidentaloma, adenoma, primary and metastatic cortical carcinoma; highly selective with a high rate of accumulation in adrenals; antitumor agents | CDC73, TPD52L2, NTRK1 | CYP3A4 105/4885ALDH1A1 1747/4885HSD17B10 810/4885 |
| US-20080009506-A1 | Imidazole Compound | KCNH2, KCNJ2, KCNH3 | CYP3A4 1244/4885ALDH1A1 2945/4885HSD17B10 3428/4885 |
| US-20050033060-A1 | Radiolabelled phenylethyl imidazole caboxylic acid ester derivatives | CDC73, BRDT, TEC | CYP3A4 777/4885ALDH1A1 2333/4885HSD17B10 1289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.