Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4890890 | 0.84 | KIF11 (0.49) | KIF11TDP2BRD9 | |
| SCHEMBL4897861 | 0.81 | KIF11 (0.72) | KIF11PDE3BPDE3ACYP1A2CYP11B1 | |
| SCHEMBL1396616 | 0.77 | KIF11 (1.00) | KIF11PDE3BPDE3AAKT1CYP1A2 | |
| SCHEMBL4596868 | 0.74 | KIF11 (0.65) | KIF11PDE3BPDE3AAKT1CYP1A2 | |
| SCHEMBL4596884 | 0.72 | KIF11 (0.59) | KIF11PDE3BPDE3AAKT1CYP1A2 | |
| SCHEMBL4596333 | 0.71 | KIF11 (0.68) | KIF11PDE3BPDE3ACYP1A2CYP11B1 | |
| SCHEMBL4888861 | 0.71 | KIF11 (0.86) | KIF11PDE3BPDE3AAKT1CYP1A2 | |
| SCHEMBL4888035 | 0.71 | KIF11 (0.86) | KIF11PDE3BPDE3AAKT1CYP1A2 | |
| SCHEMBL3310186 | 0.70 | KIF11 (0.70) | KIF11PDE3BPDE3ACYP1A2CYP11B1 | |
| SCHEMBL3307653 | 0.70 | KIF11 (0.78) | KIF11AKT1TDP2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |