Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.45 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389472 | 1.00 | RIPK1 (0.45) | RIPK1CERT1LMNABCAT2KDM4E | |
| SCHEMBL4596291 | 1.00 | RIPK1 (0.45) | RIPK1CERT1LMNABCAT2KDM4E | |
| SCHEMBL2532623 | 0.88 | TDP1 (0.44) | LMNAKDM4ESMN1; SMN2MMEACE | |
| SCHEMBL4595990 | 0.86 | AOC3 (0.43) | LMNAAOC3 | |
| SCHEMBL6050528 | 0.86 | RIPK1 (0.51) | RIPK1LMNABCAT2KDM4EL3MBTL1 | |
| SCHEMBL1529541 | 0.86 | RIPK1 (0.51) | RIPK1LMNABCAT2KDM4EL3MBTL1 | |
| SCHEMBL6050415 | 0.86 | RIPK1 (0.51) | RIPK1LMNABCAT2KDM4EL3MBTL1 | |
| SCHEMBL4595463 | 0.84 | ADRB3 (0.44) | — | |
| SCHEMBL1529741 | 0.83 | GRM2 (0.41) | RIPK1LMNALTA4HANPEP | |
| SCHEMBL4596066 | 0.82 | L3MBTL1 (0.53) | L3MBTL1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |