Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 14/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KYNU | Q16719 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596291 | 0.84 | RIPK1 (0.45) | — | |
| SCHEMBL4595044 | 0.84 | RIPK1 (0.45) | — | |
| SCHEMBL4389472 | 0.84 | RIPK1 (0.45) | — | |
| SCHEMBL4595990 | 0.83 | AOC3 (0.43) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4596066 | 0.82 | L3MBTL1 (0.53) | MEN1KMT2A | |
| SCHEMBL2532623 | 0.76 | TDP1 (0.44) | ADRB2MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL4596289 | 0.76 | ADRB2 (0.51) | ADRB1ADRB2KMT2ACYP2D6 | |
| SCHEMBL23272194 | 0.73 | MEN1 (0.43) | ADRB3ADRB1MEN1KMT2ACYP2C19 | |
| SCHEMBL23272197 | 0.73 | MEN1 (0.43) | ADRB3ADRB1MEN1KMT2ACYP2C19 | |
| SCHEMBL4598598 | 0.73 | S1PR3 (0.49) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |