Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 4/20 | 0.54 |
| ▸ | MMP9 | P14780 | 3/20 | 0.54 |
| ▸ | MMP14 | P50281 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | AOC2 | O75106 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21820745 | 0.92 | CRBN (0.53) | CRBNMMP2MMP9MMP14JAK2 | |
| SCHEMBL7356760 | 0.85 | DRD2 (0.56) | CRBNMMP2MMP9MMP14CYP3A4 | |
| SCHEMBL27659898 | 0.82 | CRBN (0.51) | CRBNMMP2MMP9MMP14JAK2 | |
| Bicarbonate SCHEMBL15103624 | 0.82 | CRBN (0.48) | CRBNMMP2MMP9MMP14JAK2 | |
| SCHEMBL14932783 | 0.81 | KMT2A (0.51) | CRBNMMP2MMP9MMP14JAK2 | |
| Hydrochloric Acid SCHEMBL1121703 | 0.81 | CRBN (0.50) | CRBNMMP2MMP9MMP14JAK2 | |
| SCHEMBL21820764 | 0.81 | CRBN (0.54) | CRBNMMP2MMP9MMP14JAK2 | |
| SCHEMBL3040016 | 0.81 | L3MBTL1 (0.46) | CRBNCYP3A4CYP2C19AOC2PKM | |
| Hydrochloric Acid SCHEMBL3043138 | 0.79 | L3MBTL1 (0.45) | CRBNCYP3A4CYP2C19AOC2PKM | |
| SCHEMBL2536571 | 0.79 | MAOA (0.40) | CRBNMMP2MMP9MMP14MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |