Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.44 |
| ▸ | ACE | P12821 | 8/20 | 0.43 |
| ▸ | REN | P00797 | 3/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PEPD | P12955 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595209 | 1.00 | DPP4 (0.44) | DPP4DPP8DPP9ACEREN | |
| SCHEMBL5734357 | 1.00 | DPP4 (0.44) | DPP4DPP8DPP9ACEREN | |
| SCHEMBL10454953 | 0.96 | TRHR (0.43) | DPP4DPP8DPP9ACEREN | |
| SCHEMBL10454951 | 0.96 | TRHR (0.43) | DPP4DPP8DPP9ACEREN | |
| SCHEMBL7759091 | 0.96 | DPP4 (0.42) | DPP4DPP8DPP9ACEREN | |
| SCHEMBL7759104 | 0.96 | DPP4 (0.42) | DPP4DPP8DPP9ACEREN | |
| SCHEMBL678488 | 0.93 | DPP4 (0.42) | DPP4DPP8DPP9ACEREN | |
| SCHEMBL678487 | 0.93 | DPP4 (0.42) | DPP4DPP8DPP9ACEREN | |
| SCHEMBL29591738 | 0.91 | TRHR (0.46) | — | |
| SCHEMBL29630592 | 0.91 | TRHR (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-85105655-A | Process for preparing novel derivatives of 1-methyl-4, 5-dihydroorotic acid and pharmaceutical compositions thereof | — | 1987-01-28 | — | — | CN | claimed |
| US-20230358751-A1 | METHODS FOR THE DETECTION AND TREATMENT OF PROSTATE CANCER | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-11-09 | — | — | US | disclosed |
| CN-101951935-A | Therapeutic agent for cerebral ischemic disorder | OTSUKA PHARMA CO LTD | 2011-01-19 | — | — | CN | disclosed |
| CN-101309682-A | Modulation of neurogenesis by pde inhibition | BRAINCELLS INC (US) | 2008-11-19 | — | — | CN | disclosed |
| EP-1442741-B1 | Compositions and methods for treating obesity | US DEPT OF VETERANS AFFAIRES A (US) | 2008-01-16 | — | — | EP | disclosed |
| US-7144865-B2 | Compositions and methods for treating obesity | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040185125-A1 | Compositions and methods for treating obesity | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2004-09-23 | — | — | US | disclosed |
| EP-1442741-A1 | Compositions and methods for treating obesity | Moon, K. Song (US) | 2004-08-04 | — | — | EP | disclosed |