Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595299 | 0.83 | RAB9A (0.41) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL1834064 | 0.83 | RAB9A (0.48) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL5310934 | 0.82 | RAB9A (0.47) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL13503893 | 0.82 | RAB9A (0.49) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL1693088 | 0.79 | RAB9A (0.44) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL5275189 | 0.78 | RAB9A (0.43) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL4596054 | 0.78 | GAA (0.45) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL704010 | 0.78 | RAB9A (0.51) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL10089204 | 0.77 | RAB9A (0.48) | RAB9AGAANOS3NOS2THRB | |
| SCHEMBL794087 | 0.77 | RAB9A (0.50) | RAB9AGAANOS3NOS2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |