Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 5/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19305417 | 0.75 | ALDH1A1 (0.41) | ALDH1A1POLBPPARGTACR1KDM4C | |
| SCHEMBL4381017 | 0.73 | ALDH1A1 (0.46) | ALDH1A1GAALMNA | |
| SCHEMBL4473207 | 0.71 | ALDH1A1 (0.46) | ALDH1A1POLBPPARGTACR1KDM4C | |
| SCHEMBL11756576 | 0.70 | ALDH1A1 (0.42) | ALDH1A1POLBPPARGTACR1DRD2 | |
| SCHEMBL4380601 | 0.70 | SLC6A4 (0.47) | ALDH1A1POLBHTR2AKDM4ELMNA | |
| SCHEMBL19312191 | 0.69 | ALDH1A1 (0.44) | ALDH1A1POLBPPARGTACR1DRD2 | |
| SCHEMBL4595541 | 0.69 | POLB (0.38) | ALDH1A1POLBGAALMNAHPGD | |
| SCHEMBL17724563 | 0.69 | ALDH1A1 (0.39) | ALDH1A1POLBTACR1DRD2HTR2A | |
| SCHEMBL7687089 | 0.69 | ALDH1A1 (0.42) | ALDH1A1POLBTACR1KDM4CMGAM | |
| SCHEMBL31688946 | 0.69 | ALDH1A1 (0.43) | ALDH1A1POLBPPARGTACR1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |