Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.35 |
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595555 | 0.79 | POLB (0.39) | POLBHTTNPSR1L3MBTL1KAT6A | |
| SCHEMBL4381017 | 0.73 | ALDH1A1 (0.46) | ALDH1A1LMNAGAA | |
| SCHEMBL13304123 | 0.73 | L3MBTL1 (0.38) | POLBHTTNPSR1L3MBTL1KAT6A | |
| SCHEMBL5067918 | 0.72 | LMNA (0.45) | POLBHTTNPSR1L3MBTL1KAT6A | |
| SCHEMBL4596146 | 0.72 | L3MBTL1 (0.48) | POLBHTTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL5061358 | 0.70 | POLB (0.43) | POLBHTTNPSR1L3MBTL1KAT6A | |
| SCHEMBL14690869 | 0.70 | POLB (0.50) | POLBHTTNPSR1L3MBTL1CA12 | |
| SCHEMBL4380601 | 0.70 | SLC6A4 (0.47) | POLBNPSR1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL4595397 | 0.69 | ALDH1A1 (0.41) | POLBALDH1A1LMNAGAAHPGD | |
| SCHEMBL4583474 | 0.69 | POLB (0.46) | POLBL3MBTL1ALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |