Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596326 | 0.88 | CNR1 (0.41) | GRM2HTR1AMAOAMAOBSMN1; SMN2 | |
| SCHEMBL4596906 | 0.85 | HTR1A (0.39) | GRM2HTR1AHTR7PTGS1PTGS2 | |
| SCHEMBL5583521 | 0.85 | NPC1 (0.37) | MAOAMAOBSMN1; SMN2NPC1TSHR | |
| SCHEMBL5595946 | 0.85 | S1PR4 (0.39) | PTGS2MAOAMAOBSMN1; SMN2NPC1 | |
| SCHEMBL4595401 | 0.84 | NPC1 (0.36) | GRM2HTR1AHTR7PTGS1PTGS2 | |
| SCHEMBL4596409 | 0.84 | PARP1 (0.39) | GRM2HTR1AHTR7MAOAMAOB | |
| SCHEMBL5605603 | 0.84 | HTR1A (0.44) | GRM2HTR1AHTR7PTGS1PTGS2 | |
| SCHEMBL5583714 | 0.83 | CNR1 (0.39) | GRM2HTR1AHTR7PTGS1PTGS2 | |
| SCHEMBL6047913 | 0.82 | GPR84 (0.45) | GRM2HTR1AHTR7SMN1; SMN2NPC1 | |
| SCHEMBL5605602 | 0.82 | HTR1A (0.35) | GRM2HTR1AHTR7PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |