Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089524 | 0.86 | HRH3 (1.00) | HRH3LMNAHRH1HRH2KCNH2 | |
| SCHEMBL22422293 | 0.79 | LMNA (0.96) | HRH3LMNA | |
| SCHEMBL18926546 | 0.77 | LMNA (1.00) | HRH3LMNA | |
| SCHEMBL5894352 | 0.77 | LMNA (0.71) | HRH3LMNALTA4H | |
| Hydrochloric Acid SCHEMBL5894403 | 0.76 | LMNA (0.69) | HRH3LMNALTA4H | |
| SCHEMBL3453099 | 0.75 | LMNA (0.79) | HRH3LMNA | |
| SCHEMBL5730258 | 0.71 | LMNA (0.79) | HRH3LMNAHRH1 | |
| SCHEMBL5730065 | 0.71 | LMNA (0.78) | HRH3LMNA | |
| SCHEMBL4083598 | 0.70 | HRH3 (0.82) | HRH3HRH1HRH2KCNH2 | |
| SCHEMBL4501961 | 0.70 | LMNA (0.81) | HRH3LMNALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874746-A2 | NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | BIOPROJET (FR) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006117609-A2 | PHENOXYPROPYLPIPERIDINES AND -PYRROLIDINES AND THEIR USE AS HISTAMINE H3 -RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-11-09 | — | — | WO | disclosed |