SCHEMBL4596276

SCHEMBL4596276

COC(=O)/C=C(/C(=O)O)C(=O)OC

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.42
KEAP1 Q14145 1/20 0.42
NFE2L2 Q16236 1/20 0.42
NPSR1 Q6W5P4 2/20 0.35
ALDH1A1 P00352 2/20 0.33
MAPT P10636 3/20 0.32
KDM4E B2RXH2 1/20 0.32
EGLN1 Q9GZT9 1/20 0.32
LMNA P02545 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6442161 0.87 HCAR2 (0.48) HCAR2KEAP1NFE2L2NPSR1ALDH1A1
SCHEMBL6901679 0.83 HCAR2 (0.37) HCAR2NPSR1ALDH1A1MAPTKDM4E
SCHEMBL17235833 0.77 ALDH1A1 (0.38) HCAR2KEAP1NFE2L2ALDH1A1MAPT
SCHEMBL17287328 0.77 ALDH1A1 (0.38) HCAR2KEAP1NFE2L2ALDH1A1MAPT
SCHEMBL14012897 0.75 HCAR2 (0.46) HCAR2KEAP1NFE2L2ALDH1A1MAPT
SCHEMBL14767817 0.75 HCAR2 (0.46) HCAR2KEAP1NFE2L2ALDH1A1MAPT
SCHEMBL1450059 0.73 HCAR2 (0.34) HCAR2KEAP1NFE2L2NPSR1
SCHEMBL2992531 0.73 HCAR2 (0.34) HCAR2KEAP1NFE2L2NPSR1
SCHEMBL5729884 0.72 HCAR2 (0.48) HCAR2KEAP1NFE2L2ALDH1A1MAPT
SCHEMBL13855084 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3863609-A1 SMALL POLYMERIC CARRIERS FOR DELIVERY OF AGENTS University of Pittsburgh - Of the Commonwealth System of Higher Education (US) 2021-08-18 EP claimed
US-20240131170-A1 CATIONIC AMPHIPHILIC POLYMERS FOR CODELIVERY OF HYDROPHOBIC AGENTS AND NUCLEIC ACIDS PITTSBURGH, UNIVERSITY OF - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2024-04-25 US disclosed
US-11857634-B2 Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2024-01-02 US disclosed
EP-3863609-A1 SMALL POLYMERIC CARRIERS FOR DELIVERY OF AGENTS University of Pittsburgh - Of the Commonwealth System of Higher Education (US) 2021-08-18 EP disclosed
EP-1875281-A1 OPTICAL COMPENSATION FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY FUJIFILM Corporation (JP) 2008-01-09 EP disclosed
WO-2007037497-A1 OPTICAL COMPENSATORY FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2007-04-05 WO disclosed
WO-2006095928-A1 OPTICAL COMPENSATION FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY FUJIFILM CORPORATION (JP) 2006-09-14 WO disclosed