Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925792 | 0.77 | AXL (0.43) | LRRK2ROCK2ROCK1DYRK1BCDC7 | |
| SCHEMBL4792269 | 0.68 | LRRK2 (0.58) | LRRK2ROCK2ROCK1DYRK1BPLK4 | |
| SCHEMBL4790325 | 0.67 | LRRK2 (0.61) | LRRK2ROCK2ROCK1DYRK1BPLK4 | |
| SCHEMBL4793527 | 0.66 | LRRK2 (0.48) | LRRK2ROCK2ROCK1DYRK1BCDC7 | |
| SCHEMBL4792632 | 0.65 | LRRK2 (0.43) | LRRK2ROCK2ROCK1DYRK1BCDC7 | |
| SCHEMBL27890843 | 0.64 | LRRK2 (0.47) | LRRK2ROCK2ROCK1DYRK1BCDC7 | |
| SCHEMBL2692623 | 0.64 | PDGFRA (0.47) | LRRK2MAP4K4CDK2KDRCDK9 | |
| SCHEMBL857300 | 0.64 | LRRK2 (0.47) | LRRK2ROCK1DYRK1BCHEK1DAPK3 | |
| SCHEMBL14462648 | 0.64 | LRRK2 (0.61) | LRRK2ROCK2ROCK1DYRK1BCDC7 | |
| SCHEMBL1266649 | 0.64 | MET (0.65) | LRRK2CDK2AXLGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885723-A2 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007013896-A2 | PYRROL (2,3-B) PYRIDINE DERIVATIVES PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-02-01 | — | — | WO | disclosed |