SCHEMBL4596686

SCHEMBL4596686

Cc1ccc(-c2cc(C(F)(F)F)cc3c2OC(C)C3)cc1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.42
MAOB P27338 2/20 0.42
BRD4 O60885 1/20 0.37
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36
PARP1 P09874 6/20 0.35
KDM1A O60341 1/20 0.34
DRD2 P14416 1/20 0.33
MAPT P10636 2/20 0.33
NPC1 O15118 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C19 P33261 1/20 0.33
RAB9A P51151 1/20 0.33
HTR1A P08908 4/20 0.32
NPBWR1 P48145 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4595688 0.92 MAOA (0.46) MAOAMAOBBRD4PARP1DRD2
SCHEMBL4597027 0.89 PARP1 (0.40) MAOAMAOBBRD4PDE3BPDE3A
SCHEMBL4596885 0.88 MAOA (0.39) MAOAMAOBBRD4PTGS1PTGS2
SCHEMBL4596683 0.86 PTGS1 (0.36) MAOAMAOBPDE3BPDE3APTGS1
SCHEMBL4596476 0.86 PTGDR2 (0.40) MAOAMAOBDRD2RAB9A
SCHEMBL4712620 0.86 MAOA (0.38) MAOAMAOBBRD4PARP1HTR1A
SCHEMBL4597185 0.84 MAOA (0.36) MAOAMAOBBRD4PDE3BPDE3A
SCHEMBL4596758 0.83 MAOA (0.43) MAOAMAOBBRD4PARP1NPC1
SCHEMBL4760717 0.83 HTR1A (0.44) MAOAMAOBBRD4KDM1ANPC1
SCHEMBL4232604 0.82 PRKAB2 (0.45) MAOAMAOBPDE3BPDE3APTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1874750-A1 DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS Wyeth Incoporated (US) 2008-01-09 EP disclosed
EP-1871355-A1 NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION Wyeth (US) 2008-01-02 EP disclosed
EP-1871354-A1 TREATMENT OF PAIN Wyeth (US) 2008-01-02 EP disclosed
WO-2007030150-A1 DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS WYETH (US) 2007-03-15 WO disclosed
WO-2006116149-A1 NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION WYETH (US) 2006-11-02 WO disclosed
WO-2006116171-A1 TREATMENT OF PAIN WYETH (US) 2006-11-02 WO disclosed
EP-1675840-A1 DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS Wyeth a Corporation of the State of Delaware (US) 2006-07-05 EP disclosed
WO-2005044812-A1 DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS WYETH A CORPORATION OF THE STATE OF DELAWARE (US) 2005-05-19 WO disclosed