Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 13/20 | 0.43 |
| ▸ | MAOB | P27338 | 6/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947753 | 0.85 | KDM4E (0.47) | KDM4ETSHRMAOAMAOBACHE | |
| SCHEMBL4596842 | 0.81 | ACHE (0.37) | KDM4ETSHRMAOBACHEBRD4 | |
| SCHEMBL4223650 | 0.80 | PRKAB2 (0.37) | MAOAACHE | |
| SCHEMBL1285321 | 0.77 | PARP1 (0.45) | KDM4ETSHRMAOAMAOBPOLL | |
| SCHEMBL30964228 | 0.76 | BRD4 (0.45) | KDM4EMAOAMAOBPOLLALDH1A1 | |
| SCHEMBL7609607 | 0.76 | BRD4 (0.45) | KDM4EMAOAMAOBPOLLALDH1A1 | |
| SCHEMBL4596565 | 0.75 | PARP1 (0.53) | KDM4ETSHRMAOAMAOBACHE | |
| SCHEMBL13894882 | 0.73 | AKR1B1 (0.42) | KDM4ETSHRMAOAMAOBPOLL | |
| SCHEMBL5543882 | 0.73 | BRD4 (0.45) | KDM4ETSHRMAOAMAOBPOLL | |
| SCHEMBL3694108 | 0.73 | BRD4 (0.41) | KDM4ETSHRMAOAMAOBPOLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |