Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 6/20 | 0.38 |
| ▸ | HTR1A | P08908 | 7/20 | 0.37 |
| ▸ | AQP1 | P29972 | 3/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596590 | 0.89 | HTR1A (0.38) | HTR2AHTR2CPARP1HTR1AAQP1 | |
| SCHEMBL4596570 | 0.86 | AQP1 (0.41) | HTR2AHTR2CPARP1HTR1AAQP1 | |
| SCHEMBL4712018 | 0.85 | AQP1 (0.40) | HTR2AHTR2CPARP1HTR1AAQP1 | |
| SCHEMBL4709866 | 0.84 | PARP1 (0.39) | PARP1HTR1AGRM2HTR7BRD4 | |
| SCHEMBL4596852 | 0.83 | HTR2A (0.46) | HTR2AHTR2CHTR1AAQP1HTR7 | |
| SCHEMBL4596424 | 0.82 | PARP1 (0.37) | PARP1HTR1AGRM2HTR7BRD4 | |
| SCHEMBL4596755 | 0.81 | MAPT (0.41) | PARP1 | |
| SCHEMBL4597090 | 0.81 | PARP1 (0.36) | PARP1HTR1AGRM2HTR7 | |
| SCHEMBL4597003 | 0.81 | GPR84 (0.40) | HTR2AHTR2CHTR1AGRM2HTR7 | |
| SCHEMBL4713784 | 0.81 | HTR1A (0.42) | PARP1HTR1AAQP1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879569-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | Wyeth (US) | 2008-01-23 | — | — | EP | claimed |
| EP-1871356-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006116221-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | WYETH (US) | 2006-11-02 | — | — | WO | claimed |
| WO-2006116170-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | claimed |
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |