Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5576017 | 0.85 | GPR119 (0.53) | HDAC1HDAC6KMT2ATP53MAPT | |
| SCHEMBL5576012 | 0.85 | GPR119 (0.53) | HDAC1HDAC6KMT2ATP53MAPT | |
| SCHEMBL4597772 | 0.82 | HTR2C (0.52) | HDAC1HDAC6KMT2ATP53MAPT | |
| SCHEMBL4597778 | 0.82 | HTR2C (0.52) | HDAC1HDAC6KMT2ATP53MAPT | |
| SCHEMBL4552094 | 0.76 | CCR5 (0.49) | CCR5 | |
| SCHEMBL4597324 | 0.74 | GPR119 (0.51) | KMT2ATP53MAPTMEN1KDM4E | |
| SCHEMBL4610243 | 0.67 | SLC18A3 (0.44) | KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3815926 | 0.67 | SLC18A3 (0.44) | KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL27341297 | 0.67 | PRMT5 (0.49) | ADAM17HSD11B1 | |
| SCHEMBL4597612 | 0.67 | GPR119 (0.52) | HDAC1HDAC6KMT2ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |