Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 4/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596976 | 0.89 | PARP1 (0.44) | PARP1NPC1RAB9ABRD4HTR1A | |
| SCHEMBL5583554 | 0.87 | PARP1 (0.40) | PARP1NPC1RAB9ABRD4HTR1A | |
| SCHEMBL4597169 | 0.84 | KDM4E (0.40) | PARP1NPC1RAB9ABRD4KDM4E | |
| SCHEMBL4595479 | 0.84 | PARP1 (0.38) | PARP1MAOAMAOBNPC1RAB9A | |
| SCHEMBL4597245 | 0.84 | FFAR4 (0.31) | FFAR4PDE3BPDE3A | |
| SCHEMBL4222492 | 0.80 | PRKAB2 (0.51) | MAOB | |
| SCHEMBL4595107 | 0.79 | PARP1 (0.42) | PARP1HTR1A | |
| SCHEMBL5583539 | 0.78 | HPRT1 (0.47) | PARP1MAOAMAOBNPC1RAB9A | |
| SCHEMBL4596609 | 0.78 | PARP1 (0.38) | PARP1MAOAMAOBNPC1RAB9A | |
| SCHEMBL4596742 | 0.78 | PARP1 (0.49) | PARP1MAOAMAOBBRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |