Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | AQP1 | P29972 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596976 | 0.88 | PARP1 (0.44) | PARP1GRM2HTR2ANPC1RAB9A | |
| SCHEMBL4597250 | 0.87 | PARP1 (0.40) | PARP1NPC1RAB9AHTR1ABRD4 | |
| SCHEMBL4597572 | 0.85 | GRM2 (0.40) | PARP1GRM2HTR1A | |
| SCHEMBL4597169 | 0.83 | KDM4E (0.40) | PARP1GRM2NPC1RAB9ABRD4 | |
| SCHEMBL5583552 | 0.82 | AHR (0.33) | AHRAQP1 | |
| SCHEMBL4706710 | 0.79 | CNR1 (0.39) | PARP1GRM2NPC1RAB9AHTR1A | |
| SCHEMBL4596326 | 0.79 | CNR1 (0.41) | PARP1GRM2NPC1RAB9AHTR1A | |
| SCHEMBL4230632 | 0.79 | AQP1 (0.54) | PARP1GRM2HTR2AAHRAQP1 | |
| SCHEMBL4963750 | 0.78 | PARP1 (0.48) | PARP1GRM2HTR2AHTR1ACNR1 | |
| SCHEMBL4595107 | 0.78 | PARP1 (0.42) | PARP1GRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |