Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 7/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597935 | 0.92 | ANO1 (0.40) | ANO1ACVR1BTGFBR1ACVRL1MDM2 | |
| SCHEMBL4598878 | 0.88 | CTSS (0.43) | ANO1SCN9A | |
| SCHEMBL4598249 | 0.84 | CTSS (0.42) | ANO1ACVR1BTGFBR1ACVRL1MDM2 | |
| SCHEMBL4599064 | 0.82 | POLB (0.34) | ANO1POLBAPEX1EGFRAURKB | |
| SCHEMBL4600646 | 0.81 | SCN9A (0.41) | ANO1GPR119SCN9A | |
| SCHEMBL4602360 | 0.80 | ANO1 (0.41) | ANO1ACVR1BTGFBR1ACVRL1EGFR | |
| SCHEMBL4598492 | 0.80 | CTSS (0.41) | ANO1SCN9A | |
| SCHEMBL4597309 | 0.78 | SCN9A (0.42) | ANO1SCN9A | |
| SCHEMBL4598164 | 0.76 | CTSS (0.42) | ANO1GPR119SCN9AAAK1 | |
| SCHEMBL4926805 | 0.76 | ANO1 (0.40) | ANO1MDM2POLBAPEX1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910274-A1 | PHENYL COMPOUNDS | Eli Lilly and Company (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015807-A1 | PHENYL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |