Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598164 | 0.90 | CTSS (0.42) | CTSSCTSKKCNA5ANO1PTPN1 | |
| SCHEMBL4598878 | 0.86 | CTSS (0.43) | CTSSCTSKKCNA5ANO1PTPN1 | |
| SCHEMBL4597310 | 0.84 | ANO1 (0.39) | ACVR1BTGFBR1ACVRL1ANO1MDM2 | |
| SCHEMBL4598492 | 0.83 | CTSS (0.41) | CTSSCTSKKCNA5ANO1PTPN1 | |
| SCHEMBL4598162 | 0.83 | CTSS (0.42) | CTSSCTSKPTPN1POLBMEN1 | |
| SCHEMBL4597935 | 0.83 | ANO1 (0.40) | ACVR1BTGFBR1ACVRL1ANO1MDM2 | |
| SCHEMBL4596927 | 0.80 | CTSS (0.43) | CTSSCTSKKCNA5ANO1PTPN1 | |
| SCHEMBL4602360 | 0.80 | ANO1 (0.41) | ACVR1BTGFBR1ACVRL1ANO1SMN1; SMN2 | |
| SCHEMBL4601576 | 0.80 | CTSS (0.42) | CTSSCTSKKCNA5ANO1PTPN1 | |
| SCHEMBL4598248 | 0.78 | CTSS (0.51) | CTSSCTSKANO1PTPN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910274-A1 | PHENYL COMPOUNDS | Eli Lilly and Company (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015807-A1 | PHENYL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |