Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 5/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.37 |
| ▸ | FLT4 | P35916 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 4/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ABL2 | P42684 | 1/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348180 | 0.93 | ALOX5 (0.44) | ALOX5KITFLT1FLT4KDR | |
| SCHEMBL2346522 | 0.91 | ALOX5 (0.48) | ALOX5KITFLT1FLT4KDR | |
| SCHEMBL2344918 | 0.85 | EGFR (0.42) | KITFLT1FLT4KDRVCP | |
| SCHEMBL10033775 | 0.84 | EGFR (0.43) | ALOX5KITFLT1FLT4KDR | |
| SCHEMBL2343197 | 0.83 | ALDH1A1 (0.47) | KITFLT1FLT4KDRGSK3B | |
| SCHEMBL2341833 | 0.83 | FLT1 (0.44) | KITFLT1FLT4KDRVCP | |
| SCHEMBL10033774 | 0.82 | ALOX5 (0.43) | ALOX5KITKDRABL1EGFR | |
| SCHEMBL10033776 | 0.80 | ALOX5 (0.47) | ALOX5KITFLT1FLT4KDR | |
| SCHEMBL2338367 | 0.80 | ALOX5 (0.47) | ALOX5KITFLT1FLT4KDR | |
| SCHEMBL543606 | 0.73 | ALOX5 (0.46) | ALOX5KITFLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874305-A2 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB Science (FR) | 2008-01-09 | — | — | EP | claimed |
| WO-2006106437-A2 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2006-10-12 | — | — | WO | claimed |