Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | VCP | P55072 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 5/20 | 0.42 |
| ▸ | FLT1 | P17948 | 6/20 | 0.42 |
| ▸ | FLT4 | P35916 | 6/20 | 0.42 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2346522 | 0.91 | ALOX5 (0.48) | ALDH1A1GAAMAPTAGTR1SMN1; SMN2 | |
| SCHEMBL10033774 | 0.83 | ALOX5 (0.43) | KITKDRABL1EGFRPDGFRB | |
| SCHEMBL4597593 | 0.83 | ALOX5 (0.41) | ALDH1A1GAAMAPTAGTR1SMN1; SMN2 | |
| SCHEMBL544406 | 0.83 | IMPDH2 (0.62) | IMPDH2VCPKITFLT1FLT4 | |
| SCHEMBL2344918 | 0.81 | EGFR (0.42) | IMPDH2VCPKITFLT1FLT4 | |
| SCHEMBL2347458 | 0.79 | KIT (0.46) | KITFLT1FLT4KDR | |
| SCHEMBL2346433 | 0.79 | IMPDH2 (0.50) | SMN1; SMN2IMPDH2KITGSK3BPRKCA | |
| SCHEMBL10033776 | 0.79 | ALOX5 (0.47) | ALDH1A1GAAMAPTAGTR1SMN1; SMN2 | |
| SCHEMBL2338367 | 0.79 | ALOX5 (0.47) | ALDH1A1MAPTAGTR1IMPDH2KIT | |
| SCHEMBL5712006 | 0.79 | ROCK2 (0.48) | ALDH1A1IMPDH2KITFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361624-A1 | Oxazole derivatives and their use as tyrosine kinase inhibitors | AB Science (FR) | 2011-08-31 | — | — | EP | claimed |
| EP-1874305-B1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2014-08-27 | — | — | EP | disclosed |
| US-8658659-B2 | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2014-02-25 | — | — | US | disclosed |
| US-8658659-B2 | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2014-02-25 | — | — | US | disclosed |
| US-8658659-B2 | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2014-02-25 | — | — | US | disclosed |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE | 2012-05-03 | — | — | US | disclosed |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE | 2012-05-03 | — | — | US | disclosed |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE | 2012-05-03 | — | — | US | disclosed |
| EP-2361624-A1 | Oxazole derivatives and their use as tyrosine kinase inhibitors | AB Science (FR) | 2011-08-31 | — | — | EP | disclosed |
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-10-02 | — | — | US | disclosed |
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-10-02 | — | — | US | disclosed |
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | KIT, TYRO3, LCK | ALDH1A1 404/4885GAA 1040/4885MAPT 4143/4885 |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | KIT, FLT3, LTK | ALDH1A1 355/4885GAA 804/4885MAPT 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.