Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598233 | 0.90 | ACE (0.41) | HDAC8ACEMEN1KMT2APOLB | |
| SCHEMBL21744471 | 0.88 | PTPN1 (0.53) | HDAC8MEN1KMT2APOLBPTPN1 | |
| SCHEMBL14097934 | 0.87 | PTPN1 (0.53) | HDAC8POLBPTPN1KDM4E | |
| SCHEMBL31569180 | 0.85 | MEN1 (0.42) | HDAC8MEN1KMT2APOLBGPR119 | |
| SCHEMBL29757597 | 0.85 | MEN1 (0.42) | HDAC8MEN1KMT2APOLBGPR119 | |
| SCHEMBL7237746 | 0.83 | GPR119 (0.38) | HDAC8MEN1KMT2APTPN1GPR119 | |
| SCHEMBL21743930 | 0.83 | MEN1 (0.43) | HDAC8MEN1KMT2APOLBGPR119 | |
| SCHEMBL66872 | 0.82 | ACE (0.59) | HDAC8ACEPOLBPTPN1 | |
| SCHEMBL2080858 | 0.82 | ACE (0.59) | HDAC8ACEPOLBPTPN1 | |
| SCHEMBL66871 | 0.82 | ACE (0.59) | HDAC8ACEPOLBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417144-B2 | e.g. 1-Methyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,5-dicarboxylic acid 5-[(4-chloro-phenyl)-amide]4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide}; anticoagulant, antiinflammatory agent; thrombosis, peripheral arterial occlusive disease, stroke, arteriosclerosis, bypass grafting | HOFFMAN-LA ROCHE INC. (US) | 2008-08-26 | — | — | US | disclosed |
| EP-1907388-A1 | NOVEL HETEROARYL FUSED CYCLIC AMINES | F. Hoffmann-Roche AG (CH) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007009883-A1 | NOVEL HETEROARYL FUSED CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-25 | — | — | WO | disclosed |
| US-20070015812-A1 | Factor Xa inhibitors | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015812-A1 | Factor Xa inhibitors | F12, F11, F2 | HDAC8 1659/4885ACE 470/4885MEN1 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.