Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | ACP3 | P15309 | 1/20 | 0.45 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 3/20 | 0.43 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | USP1 | O94782 | 1/20 | 0.41 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14393517 | 0.89 | CYP26A1 (0.46) | CYP26A1RIPK1AURKACDK2ACP3 | |
| SCHEMBL29918436 | 0.89 | CYP26A1 (0.46) | CYP26A1RIPK1AURKACDK2ACP3 | |
| SCHEMBL4580573 | 0.87 | CYP26A1 (0.50) | CYP26A1ACP3GPR139CTSAEPHX2 | |
| SCHEMBL14338245 | 0.86 | KCNA5 (0.46) | CYP26A1RIPK1AURKACDK2GPR139 | |
| SCHEMBL18765697 | 0.86 | CYP26A1 (0.47) | CYP26A1RIPK1AURKACDK2GPR139 | |
| SCHEMBL29675785 | 0.86 | CYP26A1 (0.47) | CYP26A1RIPK1AURKACDK2GPR139 | |
| SCHEMBL16783311 | 0.83 | KYNU (0.45) | RIPK1CDK2GPR88ROCK2EPHX2 | |
| SCHEMBL3446408 | 0.83 | MAPK1 (0.51) | RIPK1AURKACDK2ACP3CTSA | |
| SCHEMBL4596498 | 0.83 | MAPK1 (0.51) | RIPK1AURKACDK2ACP3CTSA | |
| SCHEMBL15996210 | 0.83 | ROCK2 (0.48) | RIPK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |